Ensuring sustainability of research projects

A wide variety of international projects and public-private partnerships encompassing all stages of biomedical research

Proven track record on
highly innovative research projects

research projects
Million Euro of funding managed
Selected projects and initiatives
Data Analysis and Real World Interrogation Network

The European Medicines Agency (EMA) is establishing a Coordination Centre to provide timely and reliable evidence on the use, safetyand effectiveness of medicines for human use, including vaccines, from realworld healthcare databases across the European Union (EU). The role of the Coordination Centre is to develop and manage a network of real-world healthcare data sources across the EU and to conduct scientific studies requested by medicines regulators and, at a later stage, also requested by other stakeholders. By supporting decision-making on medicines, a wide range of stakeholders will benefit, from patients and healthcare professionals to health technology assessment bodies, payers and the pharmaceutical industry. Additionally, DARWIN EU® will provide an invaluable resource to prepare for and respond to future healthcare crises and pandemics.

DARWIN EU® website
European Health Data & Evidence Network

The mission of the European Health Data & Evidence Network (EHDEN) is to provide a new paradigm for the discovery and analysis of health data in Europe, by building a large-scale, federated network of data sources standardised to a common data model. EHDEN will build on prior projects, such as EMIF and EHR4CR, in scaling their original intents and technologies.

EHDEN website
Efficiently Networking European Neurodegeneration Research

The main aim of NEURONET is to set up an efficient platform to boost synergy and collaboration across the IMI projects of the Neurodegenerative Disorders (ND) portfolio, assisting in identifying gaps, multiplying its impact, enhancing its visibility, and facilitating dovetailing with related initiatives in Europe and worldwide.

Neuronet website
NEURONET Knowledge Base
IT Tool designed & developed by SYNAPSE

Neuronet KB includes links to over 380 publications and more than 350 publishable deliverable report

This comprehensive resource is an integral part of NEURONET's endeavour to boost collaboration across the research portfolio by assisting in identifying gaps, multiplying the portfolio's impact and enhancing its visibility with related initiatives in Europe and worldwide.

Access KB
European Regimen Accelerator for Tuberculosis

ERA4TB (European Regimen Accelerator for Tuberculosis) project is a public-private initiative devoted to accelerating the development of new treatment regimens for tuberculosis. The ERA4TB platform is based on a progression pipeline that can cater simultaneously for a variety of molecules at different stages of development.

ERA4TB website
Enhancing Translational Safety Assessment Through Integrative Knowledge Management

The eTRANSAFE project aims at improving the safety assessment across the drug discovery and development process by applying bioinformatics approaches to shared preclinical and clinical data to systematically analyse the translatability of effects. Thus, enabling the optimisation of resources and the development of safer medicines.

eTRANSAFE website
Translational Safety Biomarker Pipeline Project

The Translational Safety Biomarker Pipeline (TransBioLine) Project aims to generate exploratory and confirmatory data supporting regulatory qualification and acceptance of novel safety biomarkers for five target organ systems (kidney, liver, pancreas, vascular, and central nervous system) for application in drug development.

TransBioLine website
IT tool designed & developed by SYNAPSE

SYNAPSE PI is a graphical interface based on the Business Intelligence dashboard model, that displays key documentation, metrics and day-to-day relevant information at a single glance.

Next Generation Health Technology Assessment

The overall objective of HTx is to create a framework for next generation Health Technology Assessment that supports patient-centred, societally oriented, real-time decision-making for integrated healthcare throughout Europe.

HTx website
Real world Outcomes across the Alzheimer’s Disease spectrum for better care: Multi-modal data Access Platform

ROADMAP aims to create the conditions for an open collaboration that yields consensual and efficient uses of RWE for the benefit of Alzheimer’s Disease patients and their caregivers. This will be achieved by using pilot studies to assess methods of data integration for patient outcomes that are useful for disease modelling; and developing tools and methods for stakeholder engagement. ROADMAP will set new standards for the collation and evaluation of RWE in Alzheimer’s Disease.

ROADMAP website
Alzheimer’s cohort metadata visualizer

3D interactive cube that allows the visualisation of the landscape on available Alzheimer's disease data in Europe.

This tool consists of a data cube that can be seen as a tree-dimensional “heat map” to interactively visualise how European data sources captures relevant AD-related outcomes. It also provides an overview of the relevance of such outcomes for different disease stages, and for different types of stakeholders. - Project Intelligence tool designed and developed by Synapse.

Access ROADMAP Data Cube
Developments of Robust and Innovate Vaccine Effectiveness

DRIVE aims at developing a governance model between public and private entities to enable a sustainable network of influenza vaccine effectiveness. This model will ensure scientific independence in the studies and full transparency, allowing different stakeholders to fulfil their needs considering their respective obligations and statutes.

DRIVE website
Translational Quantitative Systems Toxicology

TransQST aims to develop novel computational approaches using the best available data from the public and private domains to improve the understanding of adverse drug reactions (i.e., unwanted side effects of medication) to reduce significantly patient morbidity, mortality and hospitalisation costs.

TransQST website
Healthcare Alliance for Resourceful Medicines Offensive against Neoplasms in Hematology

HARMONY aims at capturing, integrating, analysing, and harmonising anonymous patient data from high-quality multidisciplinary sources to unlock valuable knowledge on haematological diseases for a better prognosis and quicker life-saving decisions for patients.

HARMONY website
Amyloid imaging to prevent Alzheimer’s Disease

AMYPAD aims at studying the onset, dynamics, and clinical relevance of brain β-amyloid in the spectrum from normal ageing, through subjective cognitive decline towards mild cognitive impairment and ultimately dementia due to Alzheimer’s Disease (AD), studying the value of β-amyloid imaging as a diagnostic and therapeutic marker for AD.

AMYPAD website
European Prevention of Alzheimer’s Dementia

EPAD aims to develop an infrastructure that efficiently enables the undertaking of adaptive, multi-arm Proof of Concept studies for early and accurate decisions on the ongoing development of drug candidates or drug combinations.

EPAD website
Projects Archive
Accelerated development of vaccine benefit-risk collaboration in Europe
Arrhythmogenic potential of drugs
European Medical Information Framework
Integrating bioinformatics and chemoinformatics approaches for the development of Expert systems allowing the in silico prediction of toxicities
Exploring and understanding adverse drug reactions by integrative mining of clinical records and biomedical knowledge
EU patient-centric clinical trial platform
Global Alignment of Immunization safety Assessment in pregnancy
Genotype-To-Phenotype Databases: A Holistic Solution
AIDS Vaccine Research Project
Therapeutic TriMix / mRNA based Vaccine in Chronic HIV-1 Infected Patients Receiving Antiretroviral Therapy
Promoting and Monitoring Biomedical Informatics
Intelligent Assessment of Pharmaceuticals in the Environment
Creating medically-driven integrative bioinformatics applications focused on oncology, CNS disorders and their comorbidities
The Neogenius Project to discover and develop new medicines for the treatment of pain in osteoarthritis patients
Treatment of late onset bacterial sepsis caused by vancomycin susceptible bacteria inneonates and infants aged under three months
Patients active in research and dialogues for an improved generation of medicines
Respiratory syncytial virus consortium in Europe
Safety Evaluation of Adverse Reactions in Diabetes
Semantic Data Platform for Healthcare
Safety Of non-Steroidal anti-inflammatory drugs