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Publications
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August 2024

A future of AI-driven personalized care for people with multiple sclerosis

Praet J, Anderhalten L, Comi G, Horakova D, Ziemssen T, Vermersch P, Lukas C, van Leemput K, Steppe M, Aguilera C, Kadas EM, Bertrand A, van Rampelbergh J, de Boer E, Zingler V, Smeets D, Ribbens A, Paul F, on behalf of the CLAIMS consortium. Frontiers in Immunology

Data-driven
AI
Multiple Sclerosis

May 2024

Semantic Harmonization of Alzheimer’s Disease Datasets Using AD-Mapper

Wegner  P, Balabin H, Ay MC, Bauermeister S, Killin L, Gallacher, J, Hofmann-Apitius M, Salimi Y, for the  Alzheimer’s Disease Neuroimaging Initiative, the Japanese Alzheimer’s Disease  Neuroimaging Initiative, for the Aging Brain: Vasculature, Ischemia, and  Behavior Study, the Alzheimer’s Disease Repository Without Borders  Investigators, for the European Prevention of Alzheimer’s Disease (EPAD)  Consortium. Journal of Alzheimer's Disease (JAD)

Neurodegeneration
Alzheimer's disease

January 2024

Validation, Deployment, and Real-World Implementation of a Modular Toolbox for Alzheimer’s Disease Detection and Dementia Risk Reduction: The AD-RIDDLE Project

Malzbender K, Barbarino P, Barkman Ferrell P, Bradshaw A, Brookes AJ, Díaz C, van der Flier WM, Georges J, Hansson O, Hartmanis O, Jönsson L, Krishnan R, MacLeod T, Mangialasche F, Mecocci P, Minguillon C, Middleton L, Pla S, Sardi SP, Schöll M, Suárez-Calvet M, Weidner W, Visser PJ, Zetterberg H, Bose N, Solomon A, Miia Kivipelto on behalf of the AD-RIDDLE Consortium. The Journal of Prevention of Alzheimer's Disease (JPAD)

Public-private partnership
Innovative Health Initiative (IHI)
Neurodegeneration
Alzheimer's disease

August 2023

Precision medicine in neurodegeneration: the IHI-PROMINENT project

Tate A, Suárez-Calvet M, Ekelund M, Eriksson S, Eriksdotter M, Van Der Flier WM, Georges J, Kivipelto M, Kramberger MG, Lindgren P, Gispert López JD, Lötjönen J, Persson S, Pla S, Solomon A, Thurfjell L, Wimo A, Winblad B, Jönsson L,  on behalf of the PROMINENT consortium. Frontiers in Neurology

Public-private partnership
Innovative Health Initiative (IHI)
Neurodegeneration
Precision Medicine

July 2023

Data sharing in neurodegenerative disease research: challenges and learnings from the innovative medicines initiative public-private partnership model

Bradshaw A, Hughes N, Vallez-Garcia D, Chokoshvili D, Owens A, Hansen C, Emmert K, Maetzler W, Killin L, Barnes R, Brookes AJ, Visser PJ, Hofmann-Apitius M, Diaz C and Steukers. Frontiers in Neurology

IMI JU
Public-private partnership
Neurodegeneration
Data Sharing

June 2023

eTRANSAFE: data science to empower translational safety assessment

Sanz F, Pognan F, Steger-Hartmann T, Díaz C and the eTRANSAFE Consortium. Nature Reviews Drug Discovery

Translational drug safety assessment
ToxHub
R&D

March 2023

Participating in innovative medicines initiative funded neurodegenerative disorder projects — An impact analysis conducted as part of the NEURONET project

Hawksworth C, Salih F, Cresswell K, Steukers L, Diaz C, Killin L, Pradier L, Bradshaw A and Dawoud D. Frontiers in Neurology

IMI JU
Public-private partnership
Neurodegeneration

January 2023

The amyloid imaging for the prevention of Alzheimer’s disease consortium: A European collaboration with global impact.

Collij LE, Farrar G, Valléz García D, Bader I, Shekari M, Lorenzini L, Pemberton H, Altomare D, Pla S, Loor M, Markiewicz P, Yaqub M, Buckley C, Frisoni GB, Nordberg A, Payoux P, Stephens A, Gismondi R, Visser PJ, Ford L, Schmidt M, Birck C, Georges J, Mett A, Walker Z, Boada M, Drzezga A, Vandenberghe R, Hanseeuw B, Jessen F, Schöll M, Ritchie C, Lopes Alves I, Gispert JD and Barkhof F. Frontiers in Neurology

Amyloid
Prognosis
Diagnosis
Alzheimer's disease

November 2022

Avoiding fragmentation: The potential of synergistic efforts across the IMI portfolio

Díaz C, Killin L, Hughes N. Front. Neurol. 2022; 13: 1050360.

Research platforms
Cohort studies
Data standardization
Public-private partnership
Neurodegeneration

November 2022

The Innovative Medicines Initiative neurodegeneration portfolio: From individual projects to collaborative networks

O’Rourke D, Coll-Padrós N, Bradshaw A, Killin L, Pradier L, Georges J, Dawoud DM, Steukers L and Díaz C. Front. Neurol. – Sec. Dementia and Neurodegenerative Diseases

IMI JU
Public-private partnership
Neurodegeneration

May 2022

The value of public‐private collaborative Real‐World Evidence platforms to monitor vaccine performance post authorization: DRIVE – a European initiative

Díez‐Domingo J, Torcel‐Pagnon L, Carmona A, Launay O, Dos Santo G, Rizzo C, Haag M, Stuurman A, Nauta J, Vannacci A, de Lusignan S, del Rey E, Levi M, Lina B, Bellino S, Nye S, Neels P, Nohynek H, Mahé C. Expert Review of Vaccines Journal

Influenza
Public-private partnership
Vaccination

March 2022

eTRANSAFE: Building a sustainable framework to share reproducible drug safety knowledge with the public domain

Sarntivijai S, Blomberg N, Lauer KB, Briggs K, Steger-Hartmann T, van der Lei J, Caves A, Sauer JM, Liwski R, Mourby M, Camprubi M, and the eTRANSAFE Consortium.  F1000Research 2022

Data mining
Data sharing
Drug safety
Drug toxicity

March 2021

The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives

Pognan F, Steger‐Hartmann T, Díaz C, Blomberg N, Bringezu F, Briggs K, Callegaro G, Capella‐Gutierrez S, Centeno E, Corvi J, Drew P, Drewe WC, Fernández JM, Furlong LI, Guney E, Kors JA, Mayer MA, Pastor M, Piñero J, Ramírez‐Anguita JM, Ronzano F, Rowell P, Saüch‐Pitarch J, Valencia A, van de Water B, van der Lei J, van Mulligen E and Sanz F. Pharmaceuticals

Data sharing
Drug safety
Drug toxicity

February 2021

Guidelines for FAIR Sharing of Preclinical Safety and Off‐Target Pharmacology Data

Briggs K, Bosc N, Camara T, Díaz C, Drew P, Drewe WC, Kors J, van Mulligen E, Pastor M, Pognan F, Quintana JR, Sarntivijai S, Steger‐Hartmann T. ALTEX

Off-target pharmacology
FAIR
Preclinical
Data sharing

November 2019

Real‐world evidence in Alzheimer’s disease: The ROADMAP Data Cube

Janssen O, Vos SJB, Garcia‐Negredo G, Tochel C, Gustavsson A, Smith M, Ly A, Nelson M, Baldwin H, Sudlow C, Bexelius C, Jindra C, Vaci N, Bauermeister S, Gallacher J, Ponjoan A, Dufoil C, Garre‐Olmo J, Pedersen L, Skoog I, Hottgenroth A, Jelle‐Visser P, van der Lei J, Díaz C. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association

EHR
RWE
Data sharing
Alzheimer's disease

January 2019

Challenges for Optimizing Real‐World Evidence in Alzheimer’s Disease: The ROADMAP Project

Gallacher J, de Reydet de Vulpillieres F, Amzal B, Angehrn Z, Bexelius C, Bintener C, Bouvy JC, Campo L, Diaz C, Georges J, Gray A, Hottgenroth A, Jonsson P, Mittelstadt B, Potashman MH, Reed C, Sudlow C, Thompson R, Tockhorn-Heidenreich A, Turner A, van der Lei J, Visser PJ, ROADMAP Consortium

Patient Outcome assessment
Data sharing
Alzheimer's disease

April 2018

A methodology for fine‐grained access control in exposing biomedical data

Trifan A, van der Lei J, Díaz C, Oliveira JL. Studies in health technologies and informatics

Data sharing
Data privacy
Data exposure

October 2017

Legacy data sharing to improve drug safety assessment: the eTOX project

Sanz F, Pognan F, Steger‐Hartmann T, Díaz C, eTOX, Cases M, et al. Nature Reviews Drug Discovery

Data sharing
Drug toxicity

July 2017

[P1–395]: AMYPAD: A European public-private partnership to investigate the value of β-amyloid brain scans as a diagnostic and therapeutic marker for Alzheimer's disease

Farrar G, Barkhof F, Pla S, Gispert JD, Foley C, Mett A, Ritchie CW, Georges J, Stephens A, Schmidt ME, Van Der Geyten S, Frisoni GB. Alzheimer's & Dementia, 13: P420-P420

Alzheimer's disease
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May 2017

Immunization in pregnancy clinical research in low- and middle-income countries – Study design, regulatory and safety considerations

Kochhar S, Bonhoeffer J, Jones CE, Muñoz FM, Honrado A, Bauwens J, Sobanjo‐ter Meulen A, Hirschfeld S.Kochhar S, Bonhoeffer J, Jones CE, Muñoz FM, Honrado A, Bauwens J, Sobanjo‐ter Meulen A, Hirschfeld S. Vaccine

Pregnancy
Immunization
Vaccination
Clinical trials

October 2016

Global alignment of immunization safety assessment in pregnancy – The GAIA project

Bonhoeffer J, Kochhar S, Hirschfeld S, Heath PT, Jones CE, Bauwens J, Honrado A, Heininger U, Muñoz FM, Eckert L, Steinhoff M, Black S, Padula M, Sturkenboom M, Buttery J, Pless R, Zuber P for the GAIA project

Medical Informatics
Big Data

June 2016

Making sense of big data in health research: Towards an EU action plan

Auffray C, Balling R, Barroso I, Bencze L, Benson M, Bergeron J, et al. Genome Medicine

Pregnancy
Immunization
Vaccination
Clinical trials

December 2014

Guia de gestió projectes Horizon 2020 (Guide for managing Horizon 2020 projects)

Honrado A, Molero E, Díaz C. ACCIÓ‐Agència per la Competitivitat de l’Empresa (Generalitat de Catalunya

Horizon2020
Management
European Projects

December 2013

Gathering and Exploring Scientific Knowledge in Pharmacovigilance

Lopes P, Nunes T, Campos D, Furlong LI, Bauer‐Mehren A, Sanz F, Carrascosa MC, Mestres J, Kors J, Singh B, van Mulligen E, Van der Lei J, Diallo G, Avillach P, Ahlberg E, Boyer S, Díaz C, Oliveira JL. Public Library of Science (PLOS ONE)

Data mining
ADR
Pharmacovigilance

December 2012

The EU‐ADR Web Platform: Delivering advanced pharmacovigilance tools

Oliveira JL, Lopes P, Nunes T, Campos D, Boyer S, Ahlberg E, van Mulligen EM, Kors JA, Singh B, Furlong LI, Sanz F, Bauer‐Mehren A, Carrascosa MC, Mestres J, Avillach P, Diallo G, Díaz C, van der Lei J. Pharmacoepidemiology and Drug Safety

ADR
EHR
Pharmacovigilance

May 2012

Knowledge engineering for health: a new discipline required to bridge the “ICT gap” between research and healthcare

Beck T, Gollapudi S, Brunak S, Graf N, Lemke HU, Dash D, Buchan I, Díaz C, Sanz F, Brookes AJ. Human Mutation

I4Health
VPH

February 2012

Electronic healthcare databases for active drug safety surveillance: is there enough leverage?

Coloma PM, Trifirò G, Schuemie MJ, Gini R, Hering R, Hippisley‐Cox J, Mazzaglia G, Picelli G, Corrao G, Pedersen L, van der Lei J, Sturkenboom M, on behalf of the EU‐ADR consortium. Pharmacoepidemiology and Drug Safety

Pharmacovigilance
Drug safety
EHR

January 2012

Automating classification of free‐text electronic health records for epidemiological studies

Schuemie MJ, Sen E, ‘t Jong GW, van Soest EM, Sturkenboom MC, Kors JA. Pharmacoepidemiology and drug safety

Data mining
Machine learning
EHR

May 2011

An Informatics Project and Online ‘‘Knowledge Centre’’ Supporting Modern Genotype‐to‐phenotype research

Webb AJ, Thorisson GA, Brookes AJ, on behalf of the GEN2PHEN Consortium. Human mutation

Computational biology
Phenotype
Genotype

January 2011

Combining electronic healthcare databases in Europe to allow for large‐scale drug safety monitoring: the EU‐ADR Project

Coloma P, Schuemie MJ, Trifirò G, Gini R, Herings R, Hippisley‐Cox J, Mazzaglia G, Giaquinto C, Corrao G, Pedersen L, van der Lei J, Sturkenboom M, on behalf of the EU‐ADR Consortium. Pharmacoepidemiology and Drug Safety

Drug safety
EHR

July 2010

In silico prediction of in vivo toxicity ‐ the first steps of the e‐Tox consortium

Steger‐Hartmann T, Pognan F, Sanz F, Díaz C, Sutter A, Pastor M. Toxicology Letters

Drug toxicity
in silico
in vivo

March 2010

XGAP: a uniform and extensible data model and software platform for genotype and phenotype

Swertz MA, van der Velde KJ, Tesson BM, Scheltema RA, Arends D, Vera G, Alberts R, Dijkstra M, Schofield P, Schughart K, Hancock JM, Smedley D, Wolstencroft K, Goble C, de Brock EO, Jones AR, Parkinson HE, members of the Coordination of Mouse Informatics Resources (CASIMIR), Genotype‐To‐Phenotype (GEN2PHEN) Consortiums, Jansen RC. Genome Biology

Phenotype
Genotype
Genetic
Genomic

December 2009

Data mining on electronic health record databases for signal detection in pharmacovigilance: which events to monitor?

Trifirò G, Pariente A, Coloma PM, Kors JA, Polimeni G, Miremont‐Salamé G, Catania MA, Salvo F, David A, Moore N, Caputi AP, Sturkenboom M, Molokhia M, Hippisley‐Cox J, Díaz C, van der Lei J, Fourrier‐Reglat A, EU‐ADR group.C. Pharmacoepidemiology and Drug Safety

Data mining
Drug toxicity
EHR

September 2009

In silico prediction of in vivo toxicities (eTox)—The Innovative Medicines Initiative Approach

Steger‐Hartmann T, Pognan F, Sanz F, Díaz C. Toxicology Letters

Drug toxicity
in silico
in vivo

September 2009

The EU-ADR Project: Preliminary Results and Perspective

Trifirò G, Fourrier-Reglat A, Sturkenboom MC, Díaz C, Van Der Lei J., EU-ADR Group. Studies in health technologies and informatics

Data mining
Drug toxicity
EHR

April 2009

Planning the Human Variome Project: The Spain Report.

Kaput J, Cotton RGH, Hardman L, Al Aqeel AI, Al‐Aama JY, Al‐Mulla F, et al. Human Mutation

Polymorphism
Phenotype
Genotype

March 2008

Training Multidisciplinary Biomedical Informatics Students: Three Years of Experience

van Mulligen EM, Cases M, Hettne K, Molero E, Weeber M, Robertson KA, Olivia B, de la Calle G, Maojo V. Journal of the American Medical Informatics Association (JAMIA)

Data collection
Medical information

October 2007

Education and research in INFOBIOMED, the European Network of Excellence in Biomedical Informatics

De la Calle G, van Mulligen EM, Molero E, Perez‐Rey D, Martín L, Crespo J, Maojo V. AMIA: Annual Symposium Proceedings

Genomics
Medical information

2005

INFOBIOMED: European Network of Excellence on Biomedical Informatics to Support Individualised

Maojo V, de la Calle G, Martín‐Sánchez F, Díaz C, Sanz F. AMIA: Annual Symposium Proceedings

Microbiology
Medical informatics

2005

The INFOBIOMED network of excellence: developments for facilitating training and mobility

De la Calle G, Benito M, Moreno JL, Molero E. Proceeding ISBMDA’05

Bioinformatics
Mobility Brokerage service

January 2004

Biomedical Informatics: From Past Experiences to the Infobiomed Network of Excellence

Maojo V, Martin‐Sanchez F, Barreiro JM, Díaz C, Sanz F. Lecture Notes in Computer Science

Bioinformatics
Medical information

November 2002

LINK3D: secure linking of organisations involved in distributed drug discovery

Díaz C, Blat J, González A, Herráiz C, Laurie B, Molero E, Palmer JLS, Pastor M, Patak A, Ramírez A, Sanz F, Soto D and the LINK3D Consortium. Challenges and Achievements in E‐business and E‐work

Drug design
Computer simulation

November 2002

Distant collaboration in drug discovery: the LINK3D project

Pastor M, Benedetti P, Carotti A, Carrieri A, Díaz C, et al. LINK3D Consortium. Journal of computer‐aided molecular design

Drug design
Computer simulation

September 2000

Information technology in community pharmacies for supporting responsible self‐medication

Sanz F, Silveira C, Díaz C, Alonso A, Loza MI, et al. American Journal of Health‐System Pharmacy

Self medication
Community pharmacy

January 2000

New technologies for the marketing and sale of medicines on the Internet and television networks

Final Study. Sanz F, Gaedt K, Alonso A, Díaz C. European Parliament DG Research (Directorate A) The STOA Programme

Data Collection
Genomics
Medical information
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